The triple-negative breast cancer MDA-MB-231 cells autophagy induced by tetrandrine was by inhibiting the PI3K/AKT/mTOR signaling via upregulating PTEN expression and downregulating p-akt ser473 /akt, p-PI3K/PI3K p110α, p-mTOR ser2448 /mTOR. Here, PTEN is linked to triple-negative breast carcinoma.