For example, IL-4 promotes IgE production by B cells [4], IL-5 causes development, recruitment, and activation of eosinophils [5], and IL-13 controls the effector phase of asthma by inducing airway hyperresponsiveness (AHR) and airway remodeling (AR), as well as hyperproduction of mucus [6]. The gene discussed is IGHE; the disease is asthma.