As shown in results, mice fed with high-fat diet were subject to serious lesions in aortic intima, which further deteriorated to be almost completely covered by plaques after the HSP65 assault (Figures 2(b) and 2(c)), indicating that HSP65 can further aggravate AS on the basic of hyperlipidemia. The gene discussed is HSPD1; the disease is hyperlipidemia.