But the level of CD80 mRNA in aortas was obviously upregulated in hyperlipidemia milieu and was further raised by HSP65, which can be reserved by simvastatin or YQHP (Figure 6(b)), indicating the weakened T cell stimulating capability of APCs linked to restrained T cell response in AS lesion areas as a result of drug intervention. The gene discussed is HSPD1; the disease is hyperlipidemia.