TNF and neoplasm of esophagus: For the other 7 diseases (Lymphoma, Colorectal Neoplasms, Esophageal Neoplasms, Hodgkin Disease, Leukemia Lymphoid, Leukemia Myeloid, and Adenocarcinoma) in CDM 1, TNF maybe their potential causal gene or have close connections with their casual genes in protein-protein interaction (PPI) network, which will be helpful for studying the pathogenesis of these diseases.