NF-kB, TNFα, MHC class II, E3 ligases, apoptosis and T-cells have all been implicated in TB susceptibility and could collectively contribute by influencing the immune response (Hirsch et al., 1999, 2005; Torres et al., 2006; Fallahi-Sichani et al., 2012; Bai et al., 2013; Parandhaman and Narayanan, 2014; Shin et al., 2015; Franco et al., 2017). This evidence concerns the gene TNF and tuberculosis.