The interaction with the lowest p-value was between rs2631914, located upstream of LINCO2153, which is upregulated in people with major depressive disorder (Cui et al., 2016), and rs8067702, located downstream of RTN4RL1), previously associated with congenital heart disease, microcephaly and mild intellectual disability (Tang et al., 2015). The gene discussed is RTN4RL1; the disease is major depressive disorder.