The major advantages of CAR T cells over other cell based therapies are (1) killing of tumor targets in a MHC independent manner and thereby overcoming certain tumor escape mechanisms such as MHC-I down regulation and faulty antigen processing, (2) engineering of multiple anti-tumor immuno-modulators, and (3) targeting wide array of antigens (protein, carbohydrate, and glycolipid). The gene discussed is HLA-C; the disease is neoplasm.