However, it is important to consider that helminth-induced polyclonal IgE activation and/or the increase of parasite-induced IgG to carbohydrate determinants in glycoproteins that cross-react with environmental allergens may block allergic hypersensitivity reaction, thus helping with the modulation of allergic diseases symptoms in chronically exposed individuals (12, 87). The gene discussed is IGHE; the disease is allergic disease.