IGHE and Increased total eosinophil count: Allergies are chronic diseases characterized by an intense and uncontrolled type-2 inflammation, with increased expression of typical cytokines such as interleukin (IL)-4, IL-5, IL-9, IL-13, eosinophilia and mast cell activation, elevated reactive immunoglobulin (Ig)E production, and increased mucus production in response to allergen exposition (1–3).