This is in agreement with epidemiological studies that evaluated allergic reactivity using Skin Prick Test (SPT) or allergen-specific IgE (sIgE) in individuals living in helminth highly endemic areas and showed an inverse association between allergen reactivity and the presence of chronic helminth infections, such as A. lumbricoides and T. trichiura in rural areas of Ecuador (34), ancylostomiasis in Southeast Asia (68), and S. haematobium in children from Gabon (24). This evidence concerns the gene IGHE and ancylostomiasis.