We then assessed the impact of anti-TNF agents (ADA, ETA), the anti-IL-6 receptor drug (TCZ), and RTX used as control on polarization surface markers in MDM from 16 RA patients and 21 healthy controls activated as M1 pro-inflammatory macrophages (Figure 2, Supplemental Figures S1–S2). Here, TNF is linked to rheumatoid arthritis.