NPPB and heart disorder: Cardiac biomarkers, such as brain natriuretic peptide (BNP) and amino-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), cardiac troponins (cTn), high sensitive C reactive protein (hs-CRP) and CRP, are currently considered to play a pivotal role in evaluating treatment strategy and prognosis of different cardiac diseases (McMurray et al., 2012; Clerico et al., 2014; Thygesen et al., 2018).