Both NT-proBNP and BNP are derived from the cleavage of BNP precursor, but NT-proBNP has longer half-life, higher plasma concentration and more stable biological properties than BNP, though both are associated with a variety of heart diseases such as left ventricular dysfunction, valvular heart disease, and acute coronary syndrome (Weber and Hamm, 2006). The gene discussed is NPPB; the disease is heart disorder.