Moreover we identified genes associated with HD-altered neurodevelopmental pathways which were dysregulated in human NSCs, like TGFβ (TGFBI) and REST (BDNF), as well as p53 pathway (CDKN1A, GADD45B), cell adhesion (TMEM132C, ANK1) and calcium signaling (CALCRL, ANXA2) (Ring et al., 2015; HD iPSC Consortium, 2017; Xu et al., 2017). The gene discussed is BDNF; the disease is Huntington disease.