What is more, cortical pathology present in Huntington’s disease, may have its molecular onset in downregulation of FLRT2 gene, which is one of the neural development regulators (Seiradake et al., 2014) and is responsible for regulation of cortical neurons migration during brain development (van Roon-Mom et al., 2008). The gene discussed is FLRT2; the disease is Huntington disease.