Moreover we identified genes associated with HD-altered neurodevelopmental pathways which were dysregulated in human NSCs, like TGFβ (TGFBI) and REST (BDNF), as well as p53 pathway (CDKN1A, GADD45B), cell adhesion (TMEM132C, ANK1) and calcium signaling (CALCRL, ANXA2) (Ring et al., 2015; HD iPSC Consortium, 2017; Xu et al., 2017). Here, ANK1 is linked to Huntington disease.