PDE4D and ischemic stroke: The PDE4D gene is located in the 5q12 region, and polymorphisms of this gene have been associated mainly with ischemic stroke and CAD in different populations, with controversial findings (Fidani et al., 2007[7]; Matsushita et al., 2009[15]; Milton et al., 2011[16]; Sinha et al., 2013[25]; Wang et al., 2017[29]).