PRMT5 protein levels are frequently high in numerous human cancers, such as lymphoma, glioblastoma, esophageal cancer, lung cancer, etc (Braun et al., 2017[4]; Chan-Penebre et al., 2015[5]; Jing et al., 2018[11]; Yan et al., 2014[23]). This evidence concerns the gene PRMT5 and esophageal cancer.