One of these is known to be triggered during inflammation and cancer and mediated by IL-6 through Janus kinase–signal transducer and activator of transcription 3 (STAT3)-induced SNAIL1 expression.55 We also evaluated gene levels of STAT1 and STAT2 expression, known as key mediators of the classic host immune defense system (Figure S14) and noted the highest increase in STAT2 gene expression under combinatorial DA treatment as compared with other conditions. This evidence concerns the gene STAT2 and cancer.