To evaluate whether binding of cellular RNA to endogenously expressed antigens could enhance de novo priming of CD8+ T cells in B6 mice, we chose a tumor-specific envelope glycoprotein (gp70) of an endogenous murine leukemia virus (AKV) that integrated as a provirus in the mouse germline DNA (https://www.uniprot.org/uniprot/P03386; https://www.genome.jp/dbget-bin/www_bget?genbank-vrl:J01998). The gene discussed is ERVW-1; the disease is neoplasm.