ANKRD11 and Down syndrome: To our knowledge, we report the first prenatally diagnosed mutations in several genes (table 2), including those associated with isolated (NR2F2 and TAB2) and syndromic congenital heart disease (primary ciliary dyskinesia associated with CCDC103 and KBG syndrome associated with ANKRD11), which indicates that WES can provide important additional information on non-cardiac prognosis.