Of the 35 genes with variants reviewed by the CRP in more than one fetus, six (17%) genes had variants that were diagnostic in more than one fetus (figure 1), and diagnostic KMT2D and CHD7 mutations (all de novo truncating) were present in fetuses with several phenotypic anomalies (KMT2D: one fetus with each of multisystem anomalies, cardiac anomalies, and hydrops; CHD7: two fetuses with multisystem anomalies and one fetus with cardiac anomalies). The gene discussed is CRP; the disease is edema.