Injured nerves from IL-2-complex-treated mice contained significantly more degenerated myelinated axons than IgG-only controls (Figures 6E and 6G, degenerated) and less abnormal axon-Schwann cell units (Figure 6G, abnormal), suggesting that such axon fibers—a feature of clinically relevant peripheral neuropathies (Sander et al., 2000)—may be targeted for degeneration by activated NK cells. The gene discussed is IL2; the disease is peripheral neuropathy.