NOTCH3 and myocardial ischemia: NOTCH3 mutations associated with myocardial ischemia (10 patients with evidence of MI—5 silent); MI predates neurological symptoms (5 patients with MI) and coronary angiography (4 patients) showed unobstructed coronaries; 1 pathology study—myocardial tissue showed no macroscopic stenosis but abnormal microvasculature