ACHE and Alzheimer disease: The inhibition of hybrid 14n towards BuChE is worth of note, as in patients with moderate to severe forms of AD, AChE activity is decreased, and BuChE, elevated49, suggesting that ACh hydrolysis in cholinergic synapses may largely occur via BuChE catalysis50 and that the specific inhibition of BuChE may be important in raising ACh levels, in order to improve the cognition impairment.51