Lei et al have demonstrated that α‐Mangostin regulates invasion of pancreatic cancer cells and suppresses PSC activation induced by hypoxia through inhibiting the stabilization of HIF‐1α and Gli1 expression.30 Overall, these data together suggest that α‐Mangostin may be beneficial for inhibiting pancreatic CSC characteristics and also by preventing pancreatic cancer progression induced by hypoxia. The gene discussed is GLI1; the disease is pancreatic neoplasm.