Sonic hedgehog pathway in pancreatic cancer has been shown to be constitutively active and plays a significant role in the initiation, progression and metastasis.3 Gli binds to GACCACCCA motif and regulates the transcription of Gli1, Patched1, Patched2, HHIP1, Myc‐N, Cyclin D1, Cyclin D2, Bcl‐2, JAG2, GREM1, CFLAR, FoXF1, FoXL1, Follistatin and PRDM1. The gene discussed is GLI1; the disease is familial pancreatic carcinoma.