It possesses antioxidant, anticancer and anti‐inflammatory properties that are highly relevant to humans.24, 25, 27, 28, 29, 30 However, the underlying molecular mechanisms of α‐Mangostin in the inhibition of pancreatic cancer by targeting CSCs and Shh‐Nanog pathway are not well understood. Here, SHH is linked to familial pancreatic carcinoma.