SIRT1 and early-onset autosomal dominant Alzheimer disease: As reported by Li, Xyu, Liu, Liu, & Wang (2015), overexpression of miR‐204 promotes apoptosis through suppressing expression of BCL2 and SIRT1. According to Zhang et al. (2017), miR‐200a‐3p promotes b‐Amyloid‐induced neuronal apoptosis through downregulation of SIRT1 in Alzheimer's disease.