In our previous studies, the imbalance in acetylation of histones facilitated by HAT (PCAF, p300) was related to cardiac hypertrophy‐mediated phenylephrine.27 This study demonstrated that hyperacetylation of H3K9ac induced by HAT (p300 and PCAF) is involved in the development and progression of cardiac hypertrophy caused by TAC. The gene discussed is EP300; the disease is cardiac hypertrophy.