Although there are currently no studies directly testing whether expansion of the TREG population attenuates hypertension during SLE, Liu et al. [76] reported that CD8+i TREG attenuate LPS-induced glomerular endothelial cell injury in female MRL/lpr lupus-prone mice by inhibiting p38 MAPK and the NF-κB pathway. The gene discussed is CD8A; the disease is systemic lupus erythematosus.