Because psoriatic keratinocytes have previously been shown to over-express mRNA transcripts for iNOS in the response to IL-8 [68] and cultured keratinocytes have been reported to produce a large amount of IL-8 during TLR2-mediated P. acnes skin infection [66], the detection of a simultaneous decrease of all inflammatory-associated mediators, i.e. nitric oxide, ROS, and IL-8 seems to be reasonable. The gene discussed is TLR2; the disease is skin infection.