Rodriguez-Broadbent et al. (2017) employed MR frameworks to study the effects of blood levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) on CRC risk. Higher concentrations of TC were associated with an increased risk of CRC (OR: 1.46, 95% CI: 1.20–1.79, P = 1.68 × 10−4). Furthermore, a genetic risk score for HMGCR, simulating the effect of statins, was associated with reduced CRC risk (OR: 0.69, 95% CI: 0.49–0.99, P = 0.046) (Rodriguez-Broadbent et al., 2017). Here, HMGCR is linked to colorectal carcinoma.