Wang et al. (2018) conducted the largest MR analysis of CRP concentration and CRC risk to-date, and failed to find evidence that CRP concentrations are causally related to risk of CRC. Nimptsch et al. (2015a) conversely found a positive relationship between CRP concentrations and CRC risk (OR: 1.74, 95% CI: 1.06–2.85). However, the study by Nimptsch et al. (2015a) considered only 727 CRC cases and 727 controls, whilst Wang et al. (2018) used data from 30,480 CRC cases and 22,844 controls. This suggests that the causal relationship reported by Nimptsch et al. (2015a) may be a false positive. Here, CRP is linked to colorectal carcinoma.