Nimptsch et al. (2017) created an ADIPOQ allele score explaining approximately 3% of the variation in circulating adiponectin, but did not find this to be significantly associated with CRC risk. Song et al. (2015) considered 19 adiponectin-associated SNPs and similarly did not find any to be significantly associated with the risk of CRC. This evidence concerns the gene ADIPOQ and colorectal carcinoma.