Tenovin‐6 is a small‐molecule inhibitor of both SIRT1 and SIRT2 that can inhibit cell growth in various cancer types.42, 43 Tenovin‐6 is known to enhance cytotoxic effects of 5‐fluorouracil and oxaliplatin in colon cancer cells.44 It has shown very encouraging in vivo effects against cancers in animal experiments.45, 46 Moreover, tenovin‐6 is more water‐soluble than tenovin‐1.45 Tenovin‐6 can inhibit protein deacetylating activities of SIRT1 and SIRT2 and promotes p53 acetylation in cancer cells.47, 48 Although its effect is limited owing to its low specificity. Here, SIRT2 is linked to malignant colon neoplasm.