The PLIN family of proteins are also known to regulate the activity of a multitude of LD associated proteins,41 including lipases such as ATGL42 and HSL.43 Future studies should examine the expression and activity of LD associated proteins such as lipid synthesis enzymes, lipases and trafficking proteins to completely characterize the regulation of lipid storage and breakdown in T2D. The gene discussed is LIPE; the disease is type 2 diabetes mellitus.