The goal of this study was to investigate the impact of T2D on LDs, autophagy and islet metabolism by assessing the expression and localization of PLIN2, TFEB, lysosome‐associated membrane protein‐2 (LAMP2) and genes associated with metabolism, oxidative stress, apoptosis and mitochondrial function in human pancreatic tissue from normal and T2D subjects. This evidence concerns the gene TFEB and type 2 diabetes mellitus.