During starvation, mTORC1 is suppressed and TFEB translocates to the nucleus and up‐regulates genes involved in autophagic and lysosomal production.23 TFEB is necessary for lipid degradation in the liver24 but its role in human pancreatic islets in the context of T2D has not been reported. The gene discussed is TFEB; the disease is type 2 diabetes mellitus.