TFEB and Hyperglycemia: We used supraphysiological levels of glucose (30 mmol/L) to model hyperglycaemia in INS‐1 cells for two reasons: (1) rat diabetic models have two‐ to threefold higher circulating glucose compared to humans56, 57; (2) previous in vitro studies using INS‐1 cells employed ≥25 mmol/L glucose to model hyperglycaemia.58, 59 Having established an important connection between autophagy dysregulation and LD accumulation in our current study, future experiments should explore whether TFEB overexpression in β‐cells can rescue islet dysfunction in vivo.