A previous study has reported that mice fed a high‐fat diet have reduced TFEB mRNA levels in pancreatic islets.45 Our observation of reduced TFEB nuclear translocation and LAMP2 protein levels in T2D islets is consistent with previous findings of reduced LAMP2 and cathepsin‐B/D gene expression in islets from T2D patients.46 Reduction in TFEB activity as a consequence of diabetes is not limited to β‐cells. This evidence concerns the gene LAMP2 and type 2 diabetes mellitus.