In both genetic and diet‐induced models of obesity, TFEB overexpressing mice had lower blood glucose levels, improved glucose tolerance and decreased fat gain compared to WT, whereas TFEB‐knockout mice experienced increased fat gain.24 Interestingly, TFEB activity is increased during physical exercise and is necessary for the beneficial effects of exercise such as increased FA oxidation, insulin response and improved mitochondrial function in skeletal muscle.51 Here, TFEB is linked to obesity due to melanocortin 4 receptor deficiency.