INS and hyperlipidemia: Results from this study show that hyperglycaemia and hyperlipidaemia in humans and rat insulin‐producing cells (INS‐1) lead to: (1) an up‐regulation of LD‐associated protein PLIN2, (2) a significant decrease in TFEB activity and in lysosomal biomarker LAMP2, consistent with inhibition of autophagy and (3) dysregulation of genes implicated in lipid metabolism, mitochondrial function and cell survival.