Conversely, the induction of IBD in mouse models could be blocked by transduction with Foxp3 into CD4+ CD25− Treg cells.6 Furthermore, the suppressive function of Treg cells was found to be dependent on the high and stable expression of transcription factor Foxp3 along with the interaction of Foxp3 with other anti‐inflammatory transcription factors, such as IL‐2 and IL‐4. Here, FOXP3 is linked to inflammatory bowel disease.