Moreover, the mutant homozygotes (AA) of rs3761548 and (CC) of rs2232365 were reported to engender an increasing risk of vitiligo in a Chinese population.12 Another study in Chinese population detected Foxp3 rs2232365, which represented a novel susceptibility locus for unexplained recurrent spontaneous abortion.13 The present study aimed to ascertain whether the Foxp3 polymorphisms rs3761547, rs2232365, rs2294021, and rs3761548 were associated with the predisposition of CD in a Chinese population. Here, FOXP3 is linked to Cowden disease.