On this basis and according to available evidence on regulation of FOXM1 by Myc and on regulation and roles of FOXM1 and EZH2 in EMT [11–14], we tested the hypothesis that the EMT-like program of melanoma cells could be regulated by an axis connecting NFATc2 to EZH2, through c-Myc and FOXM1. This evidence concerns the gene MYC and melanoma.