Silencing of c-Myc by siRNA in three different melanoma cell lines (Fig. 4a and Supplementary Fig. S14a), or treatment of melanoma cells with the c-Myc inhibitor 10058-F4 (Fig. 4a and Supplementary Fig. S14b) downregulated FOXM1, EZH2, and H3K27me3, as well as the EMT-related markers ZEB1, N- Cadherin, α-catulin and SNAIL, but upregulated E-Cadherin. This evidence concerns the gene ZEB1 and melanoma.