Importantly, despite the absence of cancer cell-expressed SLAMF7, CD47 targeting significantly induced phagocytosis of 7 out of 7 fluorescently (V450)-labeled DLBCL lines by macrophages when using F(ab′)2 fragments (Fig. 2a and Supplementary Movies 1 and 2). The gene discussed is SLAMF7; the disease is diffuse large B-cell lymphoma.