In T2D rats not given access to drinking water, a pharmacologically relevant dose of dapagliflozin (1 mg kg−1) caused glycosuria and dehydration, which resulted in increases in plasma corticosterone and catecholamine concentrations and mean arterial pressure despite a marked effect to lower plasma glucose and insulin concentrations (Fig. 3a–e, Supplementary Fig. 9a–f). Here, INS is linked to type 2 diabetes mellitus.