Besides EGF acting as a soluble factor, the increase in EGF-mediated, increased cell–cell contact might also contribute to tumor cell ITGA5 expression through cell-to-cell contact–dependent factors as described previously concerning other integrins (Chandrasekaran et al., 2000; Masszi et al., 2004; Kim et al., 2009b). This evidence concerns the gene EGF and neoplasm.