Finally, the EGF neutralizing antibody attenuated peritoneal tumor burden and increased survival in mice following peritoneal injection of SKOV3-Luc cells and CAFs (Fig. 6, H and I), accompanied by diminished ITGA5 expression in ATCs and reduced metastases in the anti-EGF treatment group compared with the IgG group (Fig. 6 J). The gene discussed is ITGA5; the disease is neoplasm.