VPS13A and neurodegenerative disease: The described endolysosomal dysfunction leading to the accumulation of vesicles with non-degraded material in VPS13A knockdown cells may be clinically relevant, as the modulation of lysosomal-related processes (such as autophagy, lysosome biogenesis or lysosomal degradation) is considered a promising potential therapeutic approach for many neurodegenerative diseases with compromised endolysosomal function (Morel et al., 2017; Sardiello, 2016).