CD274 and non-small cell lung carcinoma: For instance, pembrolizumab monotherapy in NSCLC patients with a PD-L1 tumor proportion score (TPS) < 1% (i.e., membranous PD-L1 expression on < 1% malignant cells), of 1–49%, and ≥ 50% was associated with response rates of 10.7, 16.5, and 45.2%, respectively [3].