TP53 and Li-Fraumeni syndrome: Germline TP53 mutations cause Li-Fraumeni Syndrome (LFS) (Online Mendelian Inheritance in Man [OMIM] #151623) [15]; patients with this syndrome show a predisposition for a broad spectrum of tumors, including adrenocortical carcinoma, bone and soft-tissue sarcomas, brain tumors, and early-onset BC [16].