STAT3 and hepatocellular carcinoma: HCC Huh-7 and Li-7 cells with constitutively activated STAT3 [27] were more sensitive to 2-ethoxystypandrone (1) (IC50 = 3.69 ± 0.51 μM and 5.58 ± 0.89 μM, respectively) than the HepG3B and HepG2 cells (IC50 = 16.71 ± 0.58 μM and 20.36 ± 2.90 μM, respectively).