Since 2-ethoxystypandrone (1) is structurally similar to 2-methoxystypandrone, 2-ethoxystypandronec (1) might be proposed to have the similar molecular targets such as the upstream kinase JAK2 of STAT3 signaling pathway responsible for anti-proliferative effects in HCC cells. This evidence concerns the gene STAT3 and hepatocellular carcinoma.