The patients with a higher expression of LRRFIP1/GCF2 had a better prognosis with VM-26 treatment, and the tumor volumes of GBM cells, which were transfected with a RRFIP1/GCF2-expressing plasmid and then transplanted in nude mice, saw an increased reduction with VM-26 treatment compared with a non-transfected control. The gene discussed is LRRFIP1; the disease is neoplasm.