ARHGEF12 and leukemia: Ariake et al. also showed that Leukemia-associated Rho-specific guanine nucleotide exchanging factor (LARG), which is an activator for RhoA, was bound through its Regulator of G-protein Signaling (RSG) domain by LRRFIP1/GCF2, suggesting that LRRFIP1/GCF2 activated RhoA through its interaction with LARG [15,27,28].