In glioblastoma multiforme (GBM), a human malignant brain tumor, the resistance to a topoisomerase II inhibitor teniposide (VM-26) was mediated by the over-expression of a microRNA, miR-21, which binds in the 3′-untranslated region (UTR) of LRRFIP1/GCF2 and down-regulates its expression [74]. The gene discussed is LRRFIP1; the disease is brain cancer.