As the protein encoded by one isoform of LRRFIP1/GCF2 was highly expressed in a human hepatocellular carcinoma (HCC) cell line, HepG2, and in most primary HCC tissues, LRRFIP1/GCF2 was identified as a tumor associated antigen of HCC, which could be a potential valuable biomarker for early diagnosis of HCC [71]. The gene discussed is LRRFIP1; the disease is hepatocellular carcinoma.