A previous study has indicated that the expression of TNF-α, IL-1β, and IL-6 in the colon tissues was diminished dose-dependently by a mixture of three potential probiotic strains (Lactobacillus johnsonii IDCC9203, Lactobacillus plantarum IDCC3501, and Bifidobacterium animalis subspecies lactis IDCC4301) in DSS induced colitis [37]. The gene discussed is TNF; the disease is colitis.