Hypoxic tumor cells enhance Treg recruitment, through the production of CCL28 which interacts with CXCR10 (a proangiogenic and immunosuppressive molecule) [210], the expression of neuropilin-1 (NP-1) which attracts Tregs in response to VEGF [211], or the secretion of the chemoattractant TGF-β by tumor cells [212]. This evidence concerns the gene VEGFA and neoplasm.