KLRK1 and cancer: Herein, we will discuss how cancer-derived exosomes contribute to regulate the NK cell-mediated functions in response to chemotherapeutic treatment, as well as in the presence of stress stimuli focusing on: (i) the modulation of exosome release from cancer cells under stress conditions; and (ii) the stress-induced molecules associated with cancer-derived exosomes, such as DAMPs and NKG2D ligands.