Limited evidence suggests, to the contrary, that p53 promotes in vitro and in vivo invasion of ovarian carcinoma cells isolated from PTEN; KRas mice [29], and also promotes migration and invasion of human lung, colorectal carcinoma and osteosarcoma cells by activating Rac1 or Rap2a [30,31]. This evidence concerns the gene TP53 and colorectal carcinoma.