TP53 and carcinoma: This metric showed that loss of p53 reduced invasion of the carcinoma spheroids into surrounding matrix (3.8±1.4 versus 8.4±1.5, p<0.0001 for EJ; 1.2±0.1 versus 2.8±0.8, p<0.0001 for HCT 116 in Fig 6B).