For example, miR‐125b blocks the expression of the phosphatases DUSP6 and PPP1CA as well as the anti‐apoptotic protein Bcl‐w, which in turn results in the tau hyperphosphorylation (Banzhaf‐Strathmann et al., 2014), the critical pathological changes that implicated in the dendritic abnormalities in AD (Hoover et al., 2010). This evidence concerns the gene PPP1CA and Alzheimer disease.