Therefore, we compared AARS2‐related leukoencephalopathy with three other types of common adult‐onset leukoencephalopathies to provide insight into diagnostic strategies, including leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) (Lynch et al., 2016), X‐linked adrenoleukodystrophy (X‐ALD) (Mirabella, Di Giovanni, Silvestri, Tonali, & Servidei, 2000), and metachromatic leukodystrophy (MLD) (Taylor et al., 2014) (Table 3). This evidence concerns the gene AARS2 and metachromatic leukodystrophy.