SNP variation‐associated inflammatory genes identified between COPD and lung cancer may play critical roles in a COPD‐LC transformation; activated nicotinic acetylcholine receptor gene in COPD may cause mutation and down‐regulates the expression of the crucial tumor suppressor gene TP53 and P53‐related signaling pathways, causing lung tumorigenesis.21, 22. The gene discussed is TP53; the disease is chronic obstructive pulmonary disease.