For instance for proteins CTC1, OR5B12, GTF3C5, BLVRB, SLC7A7, SLC 26A7, and Notch2 coding mutations were associated with COPD.30 Most ideally patients can be categorized for these missense mutations and treated for COPD in a much earlier phase besides prevention and assistance in the cessation of smoke in a very early stage. This evidence concerns the gene NOTCH2 and chronic obstructive pulmonary disease.