Because Notch3, one of the Notch receptors, suppresses the proliferation of trophoblasts in the placenta and functions as a tumor suppressor by inducing cellular senescence (Cui, Kong, Xu, & Zhang, 2013; Zhao, Zhuang, Huang, Feng, & Lin, 2015), the differential expression of Notch3 was first examined under different oxygen levels. This evidence concerns the gene NOTCH3 and neoplasm.