TP53 and Familial prostate cancer: Notch3 inhibits tumorigenesis by inducing p53‐p21‐associated cellular senescence of many human cells and suppresses the proliferation of placental trophoblast cells, whereas it enhances the tumor progression of human prostate cancers (Cui et al., 2013; Danza et al., 2013; Liu, Sato, Cerletti, & Wagers, 2010).