Among the highly suppressed apoptosis‐related genes, the ARS interacting multifunctional protein 3 (AIMP3/EEF1E1) was notable because AIMP3‐overexpressing mice (AIMP3 TG), a model of progeria, manifest reduced lifespan, premature aging, reduced bone density, and wrinkled skin with reduced subcutaneous adipocytes (Oh et al., 2010), although it is unknown what role AIMP3 plays in stem cell senescence in response to differential oxygen pressures. Here, EEF1E1 is linked to progeroid syndrome.