Increasing evidence demonstrates that elevated copper is essential for the growth and metastasis of solid tumours.6, 7, 8, 9 In addition to being a ligand of SOD1 and COX4, copper is found to be essential for the activation of MEK‐ and BRAF‐driven tumour growth.12, 22 Furthermore, copper is required for the activities of Memo and lysyl‐oxidase (LOX), which have been demonstrated to be involved in cancer cell migration and invasion.23, 24, 25, 26 However, the mechanisms by which copper elevation in cancer cells remain unclear. Here, MAP2K7 is linked to neoplasm.