Bevacizumab, a humanized monoclonal antibody that targets vascular endothelial growth factor (VEGF)-A, is an anti-angiogenesis agent used to treat patients with metastatic colorectal cancer (CRC) in combination with 5-fluorouracil (5-FU)-based chemotherapy as both first- and second-line treatment [1, 2]. This evidence concerns the gene VEGFA and metastatic colorectal cancer.