We then calculated pathway activation by single-sample gene set variation analysis7 on a set of actionable pathways relevant in MM: XBP1s activation, mammalian target of rapamycin signaling, histone deacetylase (HDAC), DNA repair, interleukin-6 signaling, PI3K/AKT activation, Hedgehog signaling, fibroblast growth factor receptor 3, and mitogen-activated protein kinase (MAPK). This evidence concerns the gene WNK2 and Miyoshi myopathy.