LMNA and premature aging syndrome: In this study, LMNA deficient rabbits, although not carrying human specific LMNA mutations, such as G608G (GGC>GGT), E145K (GAG>AAG), and G608S (GGC>AGC), develop several features of human premature aging syndrome and may therefore represent a promising model of premature aging syndrome [11, 33, 37, 38].