This epidemiological behavior could be explained by the recent hypothesis of the association between cigarette smoking and a decrease in body weight, using the CHRNA3 genetic variant (rs1051730); establishing that smoking does not affect body fat distribution and the increase in localized visceral fat and in abdominal obesity are due to high cortisol plasma levels and insulin resistance, respectively38–40. The gene discussed is CHRNA3; the disease is Abdominal obesity.