LDLR and obesity due to melanocortin 4 receptor deficiency: The proposed mechanisms were reducing inflammation, oxidative stress [20, 21, 41, 42], obesity, adipogenesis [20], HMG-CoA reductase, cholesterol absorption and intestinal transmission, apo-B100 expression [51], and lipogenic genes expression, increasing LDL receptors [52], regulating of some genes involved in lipoprotein [20] and lipid metabolism, anti-atherogenic effects, and statins-like functions [51].